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Surgeons prescribing antibiotics have two potentially conflicting responsibilities. First, they should offer optimal therapy for all patients under their care by offering antibiotics. Second, they should preserve the efficacy of antibiotics and minimize the development of antimicrobial resistance (AMR). The Global Alliance for Infections in Surgery and the World Society of Emergency Surgery have promoted a coalition that should call for increased awareness and action across all surgical departments worldwide in order to combat AMR. The project has been named World Antimicrobial Resistance Nationally Internationally Networking Globally in Surgery (WARNING in Surgery).